Question: Bacteria resistance to antibiotic
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gravatar for dshulgin
3.5 years ago by
dshulgin250
Belarus
dshulgin250 wrote:

Hi guys. I'm stuck with one problem.

I have an issue about Mycobacterium tuberculosis resistance to different antibiotics. Based on number of SNP's i should make a conclusion about resistance of genome that has SNP's that's given to the antibiotic.

So, i know, that there is a Hain test, that does something similar and it's based on strong SNP's (if genome has it, we have >75% probability of resistance, for example). But it will work only if it finds 1 needed SNP.

 http://www.hain-lifescience.de/en/products/microbiology/mycobacteria/genotype-mycobacterium-cmas.html

I'd like to ask you for some ideas, how i can estimate probability of resistance based on list of SNP's?

I mean, maybe there are some biology rules or biostatistics that could help me to do it.

i have type of snp (A->G etc) and position of that snp.

I appreciate any useful information (articles for ex) or ideas.

Because i don't know if such bioinformatics way exists.

Thanks.

snp gene • 949 views
ADD COMMENTlink modified 3.5 years ago • written 3.5 years ago by dshulgin250
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