Hi guys. I'm stuck with one problem.
I have an issue about Mycobacterium tuberculosis resistance to different antibiotics. Based on number of SNP's i should make a conclusion about resistance of genome that has SNP's that's given to the antibiotic.
So, i know, that there is a Hain test, that does something similar and it's based on strong SNP's (if genome has it, we have >75% probability of resistance, for example). But it will work only if it finds 1 needed SNP.
I'd like to ask you for some ideas, how i can estimate probability of resistance based on list of SNP's?
I mean, maybe there are some biology rules or biostatistics that could help me to do it.
i have type of snp (A->G etc) and position of that snp.
I appreciate any useful information (articles for ex) or ideas.
Because i don't know if such bioinformatics way exists.