I need a way to assign a number to genes representing how broken it is depending on how many SNPs with minor alleles appear on the gene. Based on just a handful of SNPs though, not every SNP.
So lets say for example I know a few SNPs for COMT:
Rs165599 AA Rs6269 AA Rs737865 AA Rs4633 TT Rs769224 GG Rs4680 AA
and some SNPs for STAT3:
Rs744166 GG Rs8069645 AG Rs9891119 CC Rs6503691 CC
and I wanna find out which gene is more defective (as in which has the most diminshed ability to encode the corresponding protein), how can I do that? These genes obviously have way more SNPs than just those ones, and in every gene I will have many minor alleles so I'm guessing its only certain SNPs that cause problems for the gene. So could I find a number that tells me how much a bad allele of a particular SNP breaks the gene and then use that number to get an overall idea of how malfunctioning the gene is?