Entering edit mode
8.4 years ago
Manuel
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410
I am looking for information on the genetic diversity within the C57BL/6 ("black six") mouse strain, something like the "one in a thousand bases" that two human genomes differ.
The best that I could find so far is the following paper by Zurita et al. that does not use NGS and thus does not capture the whole genome (or an exome).
Zurita, E., Chagoyen, M., Cantero, M., Alonso, R., González-Neira, A., López-Jiménez, A., … Montoliu, L. (2011). Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Research, 20(3), 481–489. http://doi.org/10.1007/s11248-010-9403-8
This paper focuses on sub-strains of C57BL/6 mice, I don't think it is what you really want. I think their goal was to highlight that not all C57BL/6 mice are the same, and that some SNPs can be used to determine which flavor you have.
Humans are massively outbred, so you can expect more diversity. Lab mice are not. So outside of naturally occurring polymorphisms, you shouldn't expect much/any difference.
You might be able to find enough data in SRA on mouse experiments that you could figure this out yourself. JAX also has a good resource on this: http://phenome.jax.org
This is a particularly difficult thing to say since many of the distributors recreate the lines from frozen stocks every ~20 generations. So the expected number of changes will increase and then suddenly decrease.