GWAS for rare diseases?
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8.6 years ago

Does anyone know of any genome wide association studies (GWAS) that have been performed on rare/orphan diseases? A google search just hits articles talking about rare variant and study power problems.

GWAS orphan disease rare disease • 3.6k views
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Hello starrtennis!

It appears that your post has been cross-posted to another site: http://seqanswers.com/forums/showthread.php?t=65327

This is typically not recommended as it runs the risk of annoying people in both communities.

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8.6 years ago
DG 7.3k

Most typical rare/orphan diseases are Mendelian diseases and so have been tackled with linkage mapping, candidate gene sequencing, and exome/whole genome sequencing studies within affected families. GWAS has typically been applied to the study of common diseases where you expect many different genetic variants to be involved. There have been cases of Mendelian diseases where the causative mutations are actually in more than one gene being inherited within the family (digenic, etc) but the known cases are fairly rare (but this inheritance pattern is likely more common than thought, it is just harder to detect). When studying multiple families with the same disease, but where it is known that there may be multiple potential genes mutated, it is usually some sort of linkage analysis performed with cases and controls as opposed to GWAS.

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8.5 years ago
Jason Chen ▴ 20

There are definitely a lot of rare diseases with interesting GWAS, for example just among neurodegenerative diseases, PSP, ALS, FTD, CBD all have GWAS now and are at about 10 in 100,000 population prevalence.

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