Electrostatic free energy of folding for protein (residue wise)

0

Entering edit mode

8.3 years ago

geek_bio ▴ 10

Dear All,

I want to calculate electrostatic free energy of folding for protein (residue wise). I need for identification of those residues which are destabilizing in terms of stability and potential targets for mutation.

It would be great if someone can suggest me any protocol or software for the same. I know uhbd as mentioned in 'Prediction of Functionally Important Residues Based Solely on the Computed Energetics of Protein Structure' (JMB,doi:10.1006/jmbi.2001.5009). But uhbd code is only available on request. I couldn't obtain it. So is there any way I could calculate the electrostatic free energy of folding.

Thanks a ton:) Cheers.

electrostatic mutation in-silico • 1.9k views

ADD COMMENT • link updated 21 months ago by Ram 43k • written 8.3 years ago by geek_bio ▴ 10