Question: How to know the accuracy of a Multiple Sequence Alignment?
gravatar for mithrandir
4.9 years ago by
mithrandir40 wrote:

I have a set of protein sequences which I have aligned by using different Multiple Sequence Alignment methods such as TM-Coffee, MUSCLE, multialign in MATLAB, etc. Since this set of sequences is very divergent the alignment I am getting from different tools is very different so I am searching for a way to know which of the alignments is better. There are some papers which have looked at the accuracy of the alignment methods individually but I want to have a score for each alignment and compare that to arrive at a decision. Would the sum of pairs scoring work? Any papers that have used it? 

msa protein alignment sequence • 1.8k views
ADD COMMENTlink modified 4.9 years ago by Jean-Karim Heriche23k • written 4.9 years ago by mithrandir40
gravatar for Jean-Karim Heriche
4.9 years ago by
EMBL Heidelberg, Germany
Jean-Karim Heriche23k wrote:

These papers may be of interest: Quality assessment of multiple alignment programs and Evaluating the Accuracy and Efficiency of Multiple Sequence Alignment Methods.

ADD COMMENTlink modified 11 months ago by RamRS30k • written 4.9 years ago by Jean-Karim Heriche23k
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 2022 users visited in the last hour