Question: Underdispersion issue in RNA-Seq data
gravatar for Naim.Mahi
4.8 years ago by
University of Cincinnati College of Medicine, Cincinnati, OH, USA
Naim.Mahi40 wrote:

Dear Altruists,

In most of the Rna-seq studies, people consider the data as overdispersed. I was looking for a paper that deals with underdispersion as well, but couldn't find any. 
My question is, why people usually do not consider underdispersion in rna-seq data? Why they assume that Rna-seq count data is overdispersed? Is this because biological samples always shows overdispersion in the data? If so, then why?
Any reference would be really helpful. 


Thanks in advance.


ADD COMMENTlink modified 3.3 years ago by Biostar ♦♦ 20 • written 4.8 years ago by Naim.Mahi40
gravatar for Chris Miller
4.8 years ago by
Chris Miller21k
Washington University in St. Louis, MO
Chris Miller21k wrote:

I think your last point is the most salient - we just don't observe underdispersion in practice. Start with the first answer on this previous question and see if it provides some clarity on why this is the case:

Why Does Rna-Seq Read Count Fit Poisson Distribution?

ADD COMMENTlink written 4.8 years ago by Chris Miller21k

Thanks Chris.

ADD REPLYlink modified 10 months ago by RamRS30k • written 4.8 years ago by Naim.Mahi40
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