Underdispersion issue in RNA-Seq data
1
0
Entering edit mode
6.3 years ago
Naim.Mahi ▴ 40

Dear Altruists,

In most of the Rna-seq studies, people consider the data as overdispersed. I was looking for a paper that deals with underdispersion as well, but couldn't find any. 
My question is, why people usually do not consider underdispersion in rna-seq data? Why they assume that Rna-seq count data is overdispersed? Is this because biological samples always shows overdispersion in the data? If so, then why?
Any reference would be really helpful. 

 

Thanks in advance.

 

Rna-Seq underdispersion differential expression • 1.3k views
ADD COMMENT
1
Entering edit mode
6.3 years ago

I think your last point is the most salient - we just don't observe underdispersion in practice. Start with the first answer on this previous question and see if it provides some clarity on why this is the case:

Why Does Rna-Seq Read Count Fit Poisson Distribution?

ADD COMMENT
0
Entering edit mode

Thanks Chris.

ADD REPLY

Login before adding your answer.

Traffic: 1317 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6