Pathway Analysis differences between programs

Question

[mark.preciados]

Hi all,

I am new to pathway analysis, but I am learning much as I go along. This forum is quite helpful.

I have been performing pathway analysis using Biogrid (linked from the Comparative Toxicogenomics database), as well GeneMania. I am noticing differences in the interaction pathways, mainly that GeneMania seems to show "more" information.

If this is the case, and since there are many pathway analysis software out there, how would we know which one is better and more reliable?

Any input is appreciated, and I have searched the threads, but if there is a similar one, please let me know.

Thanks.