As the rise of the NGS methylation data, such as GWBS, RRBS, we can collect more and more data for certain tissue or certain disease from SRA and GEO database. However, How to manage these data?
Since the files are usually very big. I can't keep them in the hard-disk for long time. currently, I will alignment and build the wig file to UCSC,
however, there is one critical problem for UCSC Visualizing: when we have several wig files which contain case and control, then, it is very easy to use to show the different regions. However, when the sample size or the files increased largely. How to use it? Suppose we have 200 wigs (100 case and 100 control)
Any better idea, how to collect more NGS methylation data and re-analysis them day by day as the increase of the sample?