Impact Of Genes On Diseases

Question

[Imran Ul Haq]

Hi all

I am a newbie in bioinformatics. I am working on my thesis in which the idea is to get the impact of genes on different diseases. I have processed the hedenfalk dataset and got some genes that have been repeated multiple times in the dataset for different patients. From this I get the gene index in the hedenfalk dataset. This has been done.

Now I need to see the impact of this gene on various diseases. How do I go about this task? hedenfalk dataset gives me the ImageCloneID, PlatePosition. How can I use these two values to get the required information. Which databases should I query that give me the impact of the selected genes on various diseases.

Thank you in advance.

Answer 1

[Larry_Parnell]

Search OMIM and OMIM type databases to see if the gene has been connected to disease.

Look at the phenotypes of knockout and overexpression in mouse and rat. These phenotypes are informative with regard to human disease.

Search the data (table S6) from Zhang, Becker et al (BMC Medical Genomics 2010 3:1) to see if the gene has been ascribed to one of 480 human afflictions.