Job: Principal/Senior Computer Biologist - Human Genetics
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4.6 years ago by
United Kingdom
Recruit230 wrote:

Salary £38413 to £48869 per annum depending on experience (Principal Computer Biologist)

Salary £31033 to £39142 per annum depending on experience (Senior Computer Biologist)

We are looking for an experienced computational biologist to perform research analyses and manage the informatics infrastructure for two major ongoing translational genetics studies focusing on rare developmental disorders, within the research group of Matthew Hurles, working closely with our clinical collaborators.

The Deciphering Developmental Disorders (DDD) study ( is the world’s largest genome-wide sequencing study of children with severe developmental disorders, with almost 14,000 families recruited from across the UK and Ireland. The DDD study is resulting in the diagnosis of thousands of previously undiagnosed children and is having major translation (PMID: 25529582) and research (PMID: 25533962) impact.

The Prenatal Assessment of Genomes and Exomes  (PAGE) study ( is focusing on the use of genome-wide sequencing to provide accurate prognostic information for ~1,000 UK fetuses with structural anomalies identified by prenatal ultrasound.

The vast amount of data generated by the DDD and PAGE studies require careful data management, robust processing pipelines and sophisticated research analyses.  The successful applicant for this role will work with a Senior Computational Biologist to maintain and develop the existing informatic infrastructure for the two projects. The successful applicant will also lead on specific research projects befitting their interests and expertise, leveraging these incredibly rich and powerful datasets, as an integral part of the analytical team of post-docs and students working on these studies.

Essential Skills

As detailed in the Role Profile, of particular note are strong skills and experience in UNIX/LINUX and scripting languages (e.g. Perl,Python) and expertise in genetics and/or bioinformatics.

Ideal Skills

As detailed in the Role Profile, of particular note are experience in NGS/exome analysis, familiarity with high throughput computing environments, and a track record of publications in genetics.

Other information

The Sanger Institute is a charitably funded research centre that applies the power of genomics to uncover the basis of genetic and infectious disease. We conduct science at a scale and speed that sets our research apart. Our passion is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Please include a covering letter and CV with your application.

Please apply via our website: 

Closing date: 17th February 2016

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