Question: How do I calculate the confidence interval of a mutation rate?
0
gravatar for eric.letouze
4.9 years ago by
France
eric.letouze0 wrote:

Hi,

I am estimating the mutation rates (mutations/Mb) in a series liver tumors. How can I estimate the confidence interval of each mutation rate? I tried using the binomial test (binom.test function in R) but it is quite computation intensive...

Any better idea?

Thanks you very much in advance,

Eric

sequence R genome • 1.3k views
ADD COMMENTlink modified 4.9 years ago by Jean-Karim Heriche24k • written 4.9 years ago by eric.letouze0
0
gravatar for Jean-Karim Heriche
4.9 years ago by
EMBL Heidelberg, Germany
Jean-Karim Heriche24k wrote:

The number of mutations per Mb follows a Poisson distribution. Here is a paper with 19 ways of computing a confidence interval for a Poisson mean.

ADD COMMENTlink modified 4.9 years ago • written 4.9 years ago by Jean-Karim Heriche24k
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