Yes. I think actually it can be easily split each read to two part (SRA merge two 110bp reads to one 220bp reads). However, I change my mind, I re-download it with another way which can keep the fastq file of same sample in a fold so that I can alignment and merge the bam file easily.
wget -r -c -l 2 -nH --cut-dirs=4 ftp://ftp.ddbj.nig.ac.jp/ddbj_database/dra/fastq/SRA112/SRA112056/
of course, it also can be re-download with the command:
fastq-dump --split-files --skip-technical SRR390728
fastq-dump --split-files --skip-technical SRR390729
fastq-dump --split-files --skip-technical SRR390730