DiffBind Normalization by bFullLibrarySize

Question

[simonjean434]

Hello,

I am trying to understand DiffBind in order to use it for my ATAC-seq data analysis and find differential open chromatin sites. could you please explain for me 1- why min number of raw count is 1 and not 0? 2- Regarding normalization, where bFullLibrarySize=FALSE has been used?

Thanks

[A. Domingues]

I suggest you try the bioconductor support site. It is probably the best place for specific questions regarding BioC packages, and the authors of DiffBind are quite active over there.