Job: Post-Doc positions developing NGS technologies to study RNA virus evolution at UTMB, Texas
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3.3 years ago by
andrewrouth0 wrote:

We have immediate openings for talented post-doctoral scholars in a new laboratory at the University of Texas Medical Branch (UTMB) located in Galveston, Texas. The laboratory is headed by Dr. Andrew Routh (http://www.hbcg.utmb.edu/faculty/routh.asp), who is an Assistant Professor and the most recent recruit to the faculty of the Department of Biochemistry and Molecular Biology. We are interested in applying novel Next-Generation Sequencing technologies in conjunction with molecular and cellular virology to ask basic questions about the replication and evolution of RNA viruses. We are using our recently developed 'ClickSeq' approaches, together with long-read barcoding and phasing strategies, Oxford Nanopore MinION reads, and bioinformatic platforms to study a wide range of viruses including model insect systems such as Flock House Virus in cell culture, and human pathogens including HIV in patient cohort studies. We are also collaborating with many other groups here in UTMB working on Dengue, Zika and others.

We are looking to fill two broad project areas:

  1. Development of Next-Generation Sequencing Technologies. We are seeking highly motivated and creative individuals with an interest in developing and applying Next-Generation Sequencing (NGS) technologies to study RNA virus biology, both in laboratory and clinical settings. Previous areas of interest have included developing long-read sequencing capabilities, chemical biology, and RNA modifications. We are particularly eager to develop our 'ClickSeq' protocols. Experience with molecular and biochemical techniques, NGS library preparation and downstream computational analyses is highly desirable. Experience in cell-culturing techniques and/or chemical biology are advantageous. A PhD or equivalent industry experience in a field related to biochemistry or molecular biology is required.

  2. RNA Virus Recombination and Evolution We are seeking highly motivated and creative individuals with an interest in the evolution and replication of RNA viruses. Previously, we have had a strong interest studying RNA virus assembly and genome packaging and in applying Next-Generation Sequencing strategies to study RNA recombination. We work with model systems such as Flock House Virus and other nodaviruses, and clinically important pathogens including Human Rhinoviruses and Human Immuno-deficiency Virus. Experience with cell-culture and virological techniques, RNA biology and molecular biology is highly desirable. Experience with computational biology, transcriptomics, and/or structural biology is advantageous. A PhD or equivalent industry or clinical experience in a field related to molecular biology, virology, or microbiology is required.

As a post-doc in Dr. Routh’s laboratory, s/he will have access to state-of-the-art facilities, including next-generation sequencing, genomics, high-throughput screening, structural biophysics, biological chemistry and computational biology. Moreover, UTMB boasts a renowned, vibrant and highly active community of infectious disease researchers and clinicians, providing ample opportunities for broader collaborations and development.

Post-doctoral researchers will be expected to develop novel research strategies, communicate and present their results clearly both internally as well as at public conferences, work well within a team of diverse research expertise, help train junior lab members, foster collaborations, and possess excellent writing skills. Post-docs will be encouraged, mentored and trained in view of becoming capable and independent scientists, in either an academic or industrial setting in their respective field of interest. To apply, please contact Dr. Andrew Routh at alrouth[atsym]utmb.edu with a cover letter, CV, and contact details for no fewer than three references.

About Galveston and UTMB:

Galveston is a small Texas Gulf Coast city just south of Houston, with a semitropical climate and a natural harbor. Galveston is renowned for its cultural events and seasonal activities, long beaches with fishing and boating, a rich and diverse island culture, as well as being home to UTMB. Ample opportunities exist here for interactions and affiliations with centers of scientific excellence in structural biology and molecular biophysics, biodefense, molecular medicine, cancer biology, infectious diseases, environmental health, aging, and translational sciences (http://www.utmb.edu/centers). In addition to a highly collaborative environment, UTMB offers outstanding core services, including: next-generation sequencing, organic synthesis, optical microscopy, flow cytometry, protein expression and purification, molecular biology, solution biophysics, NMR, X-ray crystallography, cryo-electron microscopy, bioinformatics, and computational chemistry (see http://www.utmb.edu/core). Excellent opportunities for scientific interactions also exist through UTMB Health’s participation in the Gulf Coast Consortia and the Keck Center for Interdisciplinary Bioscience (http://www.gulfcoastconsortia.org).

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