How to make a greedy algorithm program in python to find motif in a given DNA sequence?
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8.1 years ago
Kevin_Smith ▴ 10

In the sequence file, each line contains a single DNA sequence. I will like to try just a round of greedy algorithm starting from the first sequence and the first position. The goal is to find the motif length of 7 from the given DNA sequences in the file.

The input for the program should be the sequence file name.

The output should include:

  • the sites or kmers (each of them is a 7mer sequence from a sequence)
  • the PPM (position probability matrix) for ATCG
  • and the total information content of the PPM (for 7-mers).

For example :

Input

TCTGAGCTTGCGTTATTTTTAGACC

GTTTGACGGGAACCCGACGCCTATA

output

kmers:

TTCCT TTGCG

PPM:

A 0.091 0.091 0.091 0.091 0.091

T 0.727 0.727 0.091 0.091 0.545

total information content: 22.47

Who can help me with a python script. Thank you very much!

gene sequence alignment blast next-gen • 3.7k views
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