Does anyone know how it's possible to quantify heterogeneity between SNP mutations of the primary and metastatic site(s) of a tumor ? The goal is to possibly extrapolate about the origin of the metastatic legion and correlate a numerical index of heterogeneity with Overall Survival, Time for Progression etc. I've run across some examples but I don't know if they're applicable for what I'm asking.
I am not sure what kind of data you have, and I may have misunderstood your question, but here are anyway some tools that look at tumor heterogeneity, the clonality of the tumor and tumor purity, as well as evolutionary progression between several samples from the same patient. This list is probably incomplete.