Genes in a Pathway

Question

[Pranavathiyani G]

How can I get the list of genes involved in a particular pathway? Is there any tool or database available? For example: mTOR Signaling Pathway How can I find the list of genes which are involved in the pathway.

Answer 1

[GenoMax]

Probably multiple ways to get this information from. One is BioSystems database at NCBI. Assuming you want human mTOR data.
Original pathway link.

Answer 2

[EagleEye]

Here you can get list of genes in volved in mTOR signaling.

http://www.genome.jp/dbget-bin/www_bget?pathway+hsa04150

or use

http://rest.kegg.jp/link/genes/hsa04150

Answer 3

[cannin]

Pathway Commons has a download that gives you all the genes for each pathway in the Pathway Commons database:

http://www.pathwaycommons.org/pc2/downloads http://www.pathwaycommons.org/pc2/downloads/Pathway%20Commons.7.All.GSEA.hgnc.gmt.gz

With the paxtoolsr R package, you can get these as a list of vectors that is easy to iterate over.