Of course, a Master's Degree would be ideal but they are pricey and a full-time program would be difficult for my family (I have 2 young kids) as for 2 years I would not be bringing in any income and would be paying tuition. I could potentially work part time at least if I did an online Master's but I'm not sure if they hold the same amount of weight? The Coursera Specialization would be the easiest from a logistics perspective but I don't know if it would hold enough weight when applying for jobs to be worth the time investment. Does anybody have any thoughts on this?
Do a post-doc in the area that interests you. This used to be (still is ?) the acceptable way of switching fields. The trick is to pick the right environment in which you'll be able to grow your skills. The transition will be easier if your education gave you some good foundations in areas relevant to your new job (e.g. maths, statistics...) and has taught you how to learn by yourself.
Too expensive. You will never recover your investment in time or money.
Not familiar with these online degrees. Any credible degree would require considerable work. Paper mill degrees are detrimental rather than advantageous.
Coursera courses can be very useful for acquiring knowledge, but are generally not recognized. Yes, you should take Coursera courses to pick up skills. Just don't expect a potential employer to recognize your Coursera degree. Sell the skills you acquired through Coursera, not the Coursera degree.
Why not just pick up some Unix and programming skills on your own, using Coursera courses if you like, and then just volunteer to do bioinformatics analyses for free to pick up some experience?
What is up with all these PhDs wanting to get supplementary degrees to get a job? Very discouraging. The PhD is supposed to be a terminal degree. Surely, there must be jobs available for PhDs that do not require going back to school? Is this a real problem or the eternal student syndrome?
I think if you have a phd already and want to work again, you first off all should try to get back in touch with science. Why does it have to be 'bioinformatics'? Just try to get 'something' (postdoc or maybe part time at an institute close to your location?).... Since you did genetics - if you find something in that area, bioinformatics is right around the corner, if that is what you are interested in. But it could be easier to approach this from genetic side than to look right away for something with the job title 'bioinformatician'.
P.S.: Picking up a programming language always helps.