Different Pfam and SMART protein domains..
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5.0 years ago
kajaenilsen ▴ 10

Hi!

I'm using the Pfam and SMART databases to identify protein domains in a few protein sequences (known sequences). For EGR1 and EGR2 i get different protein domains. Pfam identifies one (EGR2) and three (EGR1) domains of unknown function, while SMART identifies 3 zinc finger domains. The domains of unknown function is not even in the same position in the sequences as the zinc finger domains are in the annotations..
How do I interpret this?

Thanks!

Pfam SMART protein domain • 2.0k views
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