I would like to purchase a desktop computer to be used by a student to run NGS pipelines for whole genome exome sequencing, RNA-seq, ChIP-seq and other similar applications. No need for Whole Genome Sequencing nor assembly pipelines.
Which desktop computer exists in the market and able to perform such tasks with a bit of parallelization (say 3/4 exome sample at a time)?
I was thinking of a desktop computer with around 12 cores (or higher if existing i.e up to 32 cores) and a minimum of 32 Gb of RAM.
Having a server is an option but I need a faster short term solution,
Any help in this matter (brand, link to a computer with such specs) is appreciated,
More RAM (64 would be better) with 12 cores would be fine for a workstation. If you are with an organization then look into local contract pricing for vendors (you may save upto 20-25% off published costs). High end workstations should perform equally well no matter which vendor you select (Dell, HP, Lenovo and others).
Mine is from DELL (I think 7810 series) and has 16 cores (32 threads), 128 GB RAM, 512 GB SSD and a two 2 TB HDDs in RAID 1. You'd be surprised how much memory some applications like clustering of NGS reads takes. No way 32 GB RAM is adequate for NGS stuff..
We recently purchased a computer from Microway. 128gb RAM, 16 cores, 8 TB storage for 5.5k USD.
It may help to say what part of the world (continent, if you don't want to be specific) you are from so you can get usable recommendations in terms of vendors.
Depending on your planned usage, it might be more interesting to consider a cloud-based solution.
Many thanks all for your replies. Very helpful.
This might do. Though a server, but pretty powerful, indeed.
Nah .. that one maxes out at 64G :-)
And the GPUs are a total waste in the context of bioinformatics..
Eh, there's some good stuff you can do with GPUs.
(but i agree a MacPro for bioinformatics is not the most cost-effective)