I have a single column data frame in R with nearly 143 dbsnp listings (in the form of rs*) and I want to fill in more columns with data such as the ancestral allele, MAF etc. What is the quickest way to do that ?
I'd use reutils. It's a wrapper in R for eutils. eutils can get you all the information you need, and you can pass a comma separated list of input IDs for a command to process and give you output in one chunk.