ExomeCNV floating CNV result
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7.9 years ago
sosal ▴ 10

Hi all.

I have been trying to use ExomeCNV to make an input for EXPANDS (tumor purity tool) (EXPANDS journal paper says "Copy-number segments were calculated using an approach similar to ExomeCNV")

This is CNV input format of EXPANDs

chr  startpos   endpos       CN_Estimate
22  26290824 51237893   1.280513
17  54279       81188538   1.723031
8    162897     146279898 1.865630
5    98191824 110460104 1.740130
14  19114214 107283536 2.016270
15  20087214  56658198  2.011064

But ExomeCNV always makes an integer copy number (CN) results. like this:

enter image description here

I used ExomeCNV functions with default parameters in R.

logR = calculate.logR(normal, tumor)
eCNV = classify.eCNV(normal=normal, tumor=tumor, logR=logR)
CNV = multi.CNV.analyze(normal, tumor, logR=logR, all.cnv.ls=list(eCNV))

My question: I want to make an floating point CN with ExomeCNV, like EXPANDS input format. What should I do?

EXPANDS CNV ExomeCNV • 2.0k views
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