I am a severely visually impaired bioinformatics graduate student. I need help in getting an overview of current techniques, methods and approaches for using genomic and other publically available data to make predictions and conclusions. Since I am legally blind I cannot achieve this objective by reading but rather I need an assistant to compensate for my visual disability. Based on this overview we need to write a literature review and then write a PhD dissertation proposal, which needs to be presented in the middle of August of 2016 and that can be completed within one year because I only have funding until May 15th, 2017. Due to lack of funding, only publically available data are available to be used for analyses in my bioinformatics PhD dissertation research.
Possible websites to look for suitable datasets for analyses are: 1) https://www.ebi.ac.uk/arrayexpress/
2) http://www.ncbi.nlm.nih.gov/sra I am thankful for any additional suggestions.
Possible aims of my bioinformatics dissertations are: 1. Predicting genes or combinations of genes that when over-or under-expressed can extend lifespan preferably in yeast but also other species are possible. We are interested in identifying changes in gene expression patterns that can be associated with an increased lifespan.
Better understand how and why caloric restriction can extend lifespan in yeast.
Identifying the factors that are responsible for a queen bee to live for up to 4 years whereas their genetically identical worker bee counterparts only live for a few weeks.
I am generally interested in making my bioinformatics dissertation a contribution to better understand and delay aging. Any approach to accomplish this is very welcome.
We can also define other aims if they are suitable for a bioinformatics PhD dissertation. So if you are already good in any techniques, methods or approaches and would like to train me in how to use them for my dissertation, I am very interested in your suggestions. Meta-analyses are also possible if we can find ways to compare data from different studies. I am very open and thankful for any kind of suggestions, ideas and recommendations since I am overwhelmed with the visually too demanding selection process for finding and implementing the best methods, techniques and approaches given the conditions described above because I am legally blind.
If you are interested in assisting me in any way to make progress with my bioinformatics PhD dissertation despite me being legally blind, please email me at Thomas.F.Hahn3@gmail.com or send me a Skype invite to my Skype ID, which is tfh002.
I am very much looking forward hearing from you.
With very warm regards