Expdiff method in differential expression analysis

Question

[fmcsky]

Hello, friends! I am a beginner about the analysis of RNA-Seq data. I found that the gene company used a "Expdiff method" to compare the known miRNA expression between two samples (without replication) to find out the differentially expressed miRNA. I would like to ask is there anybody know some more details about this method, and is there software or R package (or other package) to use this method. Thank you very much!

[GouthamAtla]

I can only fetch this ref but I never heard of this method.