What's the drawback of using penalty matrices such as BLOSUM to calculate pseudocounts?
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7.9 years ago
MT • 0

There are some different ways to decide which amino acid to choose to calculate pseudocounts. For example getting help from GenBank and ... One of the possible ways is to use penalty matrices data, but I read somewhere that this is not a proper way. Do you have any idea that what's the drawback of this approach?

sequence alignment blast sequencing • 1.3k views
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