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8.3 years ago
ahm3dhany
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20
Does anyone know if 23andme switched to GRCh38 or they are still using GRCh37?
Does anyone know if 23andme switched to GRCh38 or they are still using GRCh37?
According to Which reference genome does 23andMe use?, it's GRCh37.
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I can confirm this is currently the case by cross-referencing the coordinates in my raw 23andme data with dbSNP. (e.g. rs13096 is at coordinate 25359841, not 25206907)
Another question to clear up the confusion.. I am comparing the genotypes of rsIDs from the 23andme files versus the genotypes from snpedia.
23andme file for individual X:
on snpedia (for rs4988235):
on snpedia (for rs9939609):
after making some comparisons the results (i.e. the results i deduced):
if you noticed, in case of rs4988235 i flipped (i.e. converted) the genotype AA to TT because SNPedia shows that the orientation is minus, whereas i didn't flip the genotype for the rs9939609 because the orientation is plus.
So my question is, am I doing it the right way? I apologize if my question is naive, my background is in computer science not genomics.
Please ask this as a new question.