Question: Z-scores from log2fold change

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writersblog02 •

**50**wrote:Hi, I am learning to analyze microarray data and was wondering if you can calculate z-scores from log2fold change values in R

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modified 4.6 years ago
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Benn ♦

**8.1k**• written 4.6 years ago by writersblog02 •**50**
The formula for Z-scores is pretty straight-forward (

`z <- (logratios - mean)/stddev`

) but it requires a mean and standard deviation that define the distribution of experimental error under the null hypothesis. But we can't know what the null hypothesis is without knowing more. Could you tell us a bit more about the data you're looking at?10