Question: generating categ in mutation table for MutSigCV
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gravatar for Max
3.1 years ago by
Max130
Max130 wrote:

I have two questions about how to compute the MutSigCV mutation table's categ values:

  1. The documentation mentions that if this field is not specified in the existing maf, it can be computed using the pre-processing function of MutSigCV. However, no information is provided on how to execute this pre-processing function. What is the command-line for the pre-processing step, and what are the (minimal) input arguments/files?

    http://www.broadinstitute.org/cancer/cga/mutsig_run

  2. In some cases, I have maf files that include sequence information on sites flanking the somatic mutations. In these instances, I can compute the categ values myself, but to do so, I need to be consistent in what is defined as a CpG transition/transversion. Does a CpG mutation (whether transition or transversion) only refer to mutations in the 5' cytosine, or in either the 5' cytosine or the 3' guanine?

mutsigcv • 1.3k views
ADD COMMENTlink modified 3.1 years ago • written 3.1 years ago by Max130
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