Question: cBioPortal survival analysis help
gravatar for doc.golly
4.0 years ago by
doc.golly50 wrote:

dear cBioPortal team and users,

In cBioPortal's survival analysis (web portal), when stratifying samples into "with/without Cases with Alteration(s) in Query Gene(s)" based on a gene list, how is the overall with/without Cases with Alteration(s) groups in Query Gene(s) stratified (/calculated?

For example in Select Genomic Profiles: mRNA Expression z-Scores (RNA Seq V2 RSEM): Enter a z-score threshold ±:2 Tumor Samples with mRNA data (RNA Seq V2) (498 samples) / 40 Genes

I assume alteration here is mRNA Upregulation vs mRNA Downregulation for each gene. So, for each gene each sample has a z-score (indicate relative over- or under-expression for each gene in comparison to the rest of the cohort), but I am not sure where to go from here when it comes to dividing the samples into two distinct groups.

all the best, doc golly

cbioportal tcga • 3.3k views
ADD COMMENTlink modified 3.4 years ago by edco840 • written 4.0 years ago by doc.golly50
gravatar for edco84
3.4 years ago by
edco840 wrote:

Alteration means that the Z score of that gene is 2 standard deviations away from the Z scores of the selected data. You can try playing around this cutoff.

ADD COMMENTlink written 3.4 years ago by edco840
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