I just downloaded pre-formated nt database from ncbi and the latest version of blastn. When I try to blast single sequence (with 1427 nucleotids length) blastn just eats all of my RAM (around 95%) and the process takes really really long time (around 20 mins against 3 mins with -remote blast). On my PC I have Windows 7 64x, amd fx-8350 and 8 gb of RAM.
I use these parameters and they looks for me pretty similar to the parameters in default blastn search in the online version of blast. (db="nt", max_target_seqs = 100, task = "blastn", num_threads = 8, outfmt=5)
Can you please explain what am I doing wrong? Or maybe my PC isn't good enough and I should buy more RAM?