Question: In FACETS, what does the mafR value represent?
gravatar for sviatoslav.kendall
20 months ago by
United States
sviatoslav.kendall430 wrote:

I've been working with some copy number data produced using FACETS and I'm just wondering if anyone knows what the "mafR" values represent. I've read the documentation but found nothing explaining what this value means.

cnv • 569 views
ADD COMMENTlink modified 9 months ago by bruce.moran370 • written 20 months ago by sviatoslav.kendall430
gravatar for bruce.moran
9 months ago by
bruce.moran370 wrote:

Probably a bit old but I am working through this method, so:

'mafR’ the log-odds-ratio summary for the segment

This represents the ratio of counts of heterozygous sites in the tumour/normal pair (log-ratio is the ratio of total counts in tumour/normal pair). The idea behind this is that the variant/minor/'B' allele frequency (where I believe the 'mafR' name comes from: minor allele frequency ratio) can tell you if a region has loss of heterozygosity, even when it is copy-number neutral.

ADD COMMENTlink written 9 months ago by bruce.moran370
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