Question: Validate a composite regulatory network
gravatar for Vinay
3.7 years ago by
Vinay30 wrote:

How can we validate a composite biological network, comprising mRNA, transcription factors, miRNA, and signaling molecules, which has been inferred from various individual databases hosting experimental data? The network has been created by identifying small regulatory components (eg., miRNA-mRNA, TF-mRNA, and TF-miRNA) and merging them altogether by in house scripts.

ADD COMMENTlink modified 3.7 years ago by Biostar ♦♦ 20 • written 3.7 years ago by Vinay30

What do you mean by validating a network ? Experimentally testing the existence of (some of) the edges ?

ADD REPLYlink written 3.7 years ago by Jean-Karim Heriche22k

Not experimentally, but validating the network (sub-networks) using computational approaches.Any ideas?

ADD REPLYlink written 3.7 years ago by Vinay30
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