Segment genes into functional subsets

Question

[Saad Khan]

Hi,

I have a list of around 14k orthologus genes across some mammalian species. I need to do some comparisons based on their epigenome. But before that I need to divide the genes into independent functional subsets. I have tried GO-Slim but as given in the plot below it does not give me what I want. In GO-slim most GO terms are child nodes of another parent Go term that is also present in GO mappings. Thus they are not independent. I understand most things in biology are interrelated but I believe people have tried to divide sets of genes before based on their functionality into independent subsets. I would be happy if someone could give me pointers to the same.

regards