how to calculate p-value for genes in R

Question

[nzarayeneh]

Hello, I have a huge data set of genes I ned to know how to calculate p-values for them, actually i want to use volcano plot, I already calculate fold change now i have to calculate p-values, I will appreciate any help. Thnaks, Neda

[Devon Ryan]

Exactly what sort of data do you have? A "huge data set of genes" doesn't mean much to us.