I am carrying out rare variant burden analysis on a quantitative trait. I have run this using the cmc method in RVTests, however I need to calculate a beta coefficient for each gene to see the direction of effect. I'm not sure how to go about doing this or even if this can be done for a cmc test.
Also, I have tried running the cmcWald test as this computes the beta coefficient and standard errors, however I'm having trouble interpreting the output. Each gene has 9 different p-values associated with it.Has anyone ran a similar test who would be able to help interpret this?
Any help would be greatly appreciated.