Predict if the mutation is activating or deactivating
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8.1 years ago
Chirag Nepal ★ 2.4k

Hi there,

Does anyone know a tool that can predict whether a given SNV/INDEL has activating or deactivating effect. There are many tools that can predict whether a mutation is deleterious or not. But i did not find information regarding if that mutation is activating or deactivating.

thanks !!

SNV INDEL Activating Deactivating mutations • 3.0k views
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for activating mutation you meant "gain of function" mutations?

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I was thinking X-Men.

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Yes, i meant gain of function.

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8.1 years ago
Amitm ★ 2.3k

hi, In case your interest is in human samples, then have a look at OncoKB and MutationAssesor. Not everything under the sun is 'annotated' though, in fact for OncoKB it is a select few. Both of the above are used in the cBioPortal data

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