Question: Predict if the mutation is activating or deactivating
0
gravatar for Chirag Nepal
4.2 years ago by
Chirag Nepal2.3k
Copenhagen
Chirag Nepal2.3k wrote:

Hi there,

Does anyone know a tool that can predict whether a given SNV/INDEL has activating or deactivating effect. There are many tools that can predict whether a mutation is deleterious or not. But i did not find information regarding if that mutation is activating or deactivating.

thanks !!

ADD COMMENTlink modified 4.2 years ago • written 4.2 years ago by Chirag Nepal2.3k

for activating mutation you meant "gain of function" mutations?

ADD REPLYlink written 4.2 years ago by fusion.slope240
4

I was thinking X-Men.

ADD REPLYlink written 4.2 years ago by John12k

Yes, i meant gain of function.

ADD REPLYlink written 4.2 years ago by Chirag Nepal2.3k

hi, In case your interest is in human samples, then have a look at OncoKB and MutationAssesor. Not everything under the sun is 'annotated' though, in fact for OncoKB it is a select few. Both of the above are used in the cBioPortal data

ADD REPLYlink written 4.2 years ago by Amitm2.0k
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1205 users visited in the last hour