Question: iron metabolism pathway
0
gravatar for rob.costa1234
3.4 years ago by
rob.costa1234200
United States
rob.costa1234200 wrote:

I am looking for a pathway (similar to IPA/ KEGG etc) for iron metabolism. I dot find such pathway in Ingenuity KEGG or any other general pathway data bases use. If some one has studied such pathway can they direct me to this pathway. I have to study enrichment of microRNA target mRNAs.

pathway • 1.2k views
ADD COMMENTlink modified 2.2 years ago by Shicheng Guo8.0k • written 3.4 years ago by rob.costa1234200

If you were interested in the genes/diseases with that phenotype in mind, you could explore the Platform for drug identification in Open Targets. You could search for iron metabolism, and find the diseases and genes where the search term matches to (at the moment we've got 222 targets associated with iron metabolism, only one based on 'Affected pathways' i.e. CP. You can also explore CP for more information including 'Pathways', with the one highlighted by @b.nota plus two others.

ADD REPLYlink modified 3.1 years ago • written 3.4 years ago by Denise - Open Targets5.1k

The hyperlinked 'Open Targets' should take you to this Biostars post instead.

ADD REPLYlink written 3.4 years ago by Denise - Open Targets5.1k

How to understand the concept: iron biomarker measurement?

ADD REPLYlink written 2.2 years ago by Shicheng Guo8.0k
1
gravatar for Benn
3.4 years ago by
Benn7.9k
Netherlands
Benn7.9k wrote:

Did you try the REACTOME?

http://www.reactome.org/PathwayBrowser/#/R-HSA-917937

ADD COMMENTlink written 3.4 years ago by Benn7.9k

Think this qualifies as a correct answer. Btw, found http://www.genome.jp/dbget-bin/www_bget?hsa04978 as the top hit with google. What you choose as "iron pathway" is vastly arbitrary. You can extend this pathway to include:

  • iron uptake receptors and transport
  • iron containing proteins (include heme and heme binding proteins?)
  • iron storage proteins, e.g. ferritin
  • iron regulatory proteins (e.g. IRP)
ADD REPLYlink modified 3.4 years ago • written 3.4 years ago by Michael Dondrup47k
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