Question: ChromHMM 15 State Descriptions (Genic Enhancer)
1
gravatar for QVINTVS_FABIVS_MAXIMVS
2.5 years ago by
USA SoCal
QVINTVS_FABIVS_MAXIMVS2.2k wrote:

I'm working with the ChromHMM predictions in 127 consolidated epigenomes. I'm wondering where can I find biological descriptions for the 15 core states?

For example what's the difference between a Genic Enhancer and an Enhancer?

I assume the Genic Enhancer directly contacts a promoter (then what's the difference with an Enhancer)

I can't seem to find the needed documentation.

http://egg2.wustl.edu/roadmap/web_portal/chr_state_learning.html

ADD COMMENTlink modified 13 months ago by oneillkza70 • written 2.5 years ago by QVINTVS_FABIVS_MAXIMVS2.2k
1

Hey.. I am in search of same answer. Did you figure it out somehow?

ADD REPLYlink written 2.1 years ago by Bioinformatist Newbie230
2
gravatar for oneillkza
13 months ago by
oneillkza70
Canada
oneillkza70 wrote:

If you look at the "GeneAnno" plot (ie genomic region annotations), "genic enhancers" occur more frequently in gene bodies, and occur in exons, while "enhancers" (state 7) occur less frequently in gene bodies and almost never in exons. Both seem to occur in introns with equal frequency. If you dig into the raw data, you can also see that the "genic enhancers" occur at TSS about twice as frequently. Also, the "genic enhancers" occur about 26 times less frequently genome-wide.

http://egg2.wustl.edu/roadmap/data/byFileType/chromhmmSegmentations/ChmmModels/coreMarks/jointModel/final/annotationEnrichment_RoadmapEp_coreMarks_15State.png

http://egg2.wustl.edu/roadmap/data/byFileType/chromhmmSegmentations/ChmmModels/coreMarks/jointModel/final/E003_15_coreMarks_geneAnno_overlap.txt

It's important to note that these are probabilistic categories based solely on the histone marks -- there are probably some promoters/TSS mixed in with the regions annotated as genic enhancers. Conversely, many of the genic enhancers may be located intergenically. Lastly, there is no guarantee that any of the regions annotated as enhancers actually function as such. If they do function as enhancers, then they must, by necessity, be brought into proximity to promoters via enhancer-promoter looping. This mechanism functions regardless of whether they are genic or intergenic.

ADD COMMENTlink written 13 months ago by oneillkza70

Seems so obvious now. Thanks!

ADD REPLYlink written 13 months ago by QVINTVS_FABIVS_MAXIMVS2.2k
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