Question: Polyprotein phylogeny: substitution rate matrix
0
gravatar for Sebastian L
2.2 years ago by
Paris, France
Sebastian L0 wrote:

Hi everyone,

Please excuse me if the question is trivial, but i wasn't able to find any clear answer for this question anywhere yet...

I'm aligning amino-acid sequences which are part of a virus polyprotein (spans end of gene 1 and beginning of gene 2), which means all genes are translated during the same process and with the same mechanism (proteins are cleaved after translation).

I wonder if I can create a ML phylogenetic tree using with my whole sequence (i.e. 1 substitution rate matrix for both genes) or if I should create one tree per gene fragment even if they are translated as a polyprotein.

Thank you very much for your help!

ADD COMMENTlink written 2.2 years ago by Sebastian L0
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