chi squared test for comparing two groups of proteins

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7.5 years ago

Sudheer Gupta ▴ 40

Hi all,

Can somebody please help me identifying significant amino acid variations in two groups of proteins? There are amino acid sequence variations in the envelop protein E2 of a virus. I need to identify the variation (amino acids) which are significantly different in severe virus from non-severe virus. I have 1000 E2 proteins from severe virus and 500 E2 proteins from non-severe virus. Can we know the significantly differing variations/locations in these two classes?. I have heard of applying Chi squared test for this problem but do not know how to apply it on amino acid sequences.

Thanks in advance.

Sudheer

sequence R • 1.6k views

ADD COMMENT • link 7.5 years ago by Sudheer Gupta ▴ 40

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What do you mean by significantly different in proteins?

ADD REPLY • link 7.5 years ago by H.Hasani ▴ 990

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There are amino acid sequence variations in the envelop protein E2 of a virus. I need to identify the variation (amino acids) which are significantly different in severe virus from non-severe virus. I have 1000 E2 proteins from severe virus and 500 E2 proteins from non-severe virus. Can we know the significantly differing variations/locations in these two classes?

ADD REPLY • link 7.5 years ago by Sudheer Gupta ▴ 40

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