Question: Metabolic gene database: The most-frequently mutated metabolic genes in human cancers
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gravatar for Mike
4.4 years ago by
Mike1.7k
UK
Mike1.7k wrote:

Hi all,

I am looking a list of the most-frequently mutated metabolic genes in human cancers, could you please suggest me related database/resources.

Thanks

gene • 1.5k views
ADD COMMENTlink modified 4.4 years ago by sacha2.1k • written 4.4 years ago by Mike1.7k

Other people had better answers but this may also be helpful: http://www.hmdb.ca/ This is Human Metabolome Database and I think they have links to some KEGG pathways, some which are relevant for cancers, and you could try to dig up mutations in those pathways.

ADD REPLYlink written 4.4 years ago by jiwpark00210
0
gravatar for Manvendra Singh
4.4 years ago by
Manvendra Singh2.1k
Berlin, Germany
Manvendra Singh2.1k wrote:

I don't think any such database is there to my knowledge. Mutations could cause cancer (BRCA, BRAF, TP53 etc), cancer could cause mutations (L1 retrotransposition, edited retrogenes etc etc.)

your query could be done by downloading somatic mutation database in human cancers from cosmic

then you get the gene lists that's harbouring frequent mutations followed by its pathway or ontology analysis to see if they fall into metabolic pathways

hth

ADD COMMENTlink written 4.4 years ago by Manvendra Singh2.1k
0
gravatar for sacha
4.4 years ago by
sacha2.1k
France
sacha2.1k wrote:

Did you check TCGA portal : https://gdc-portal.nci.nih.gov/ and ICGC portal https://dcc.icgc.org/ ? They are some filter where you can query a gene list.

ADD COMMENTlink modified 4.4 years ago • written 4.4 years ago by sacha2.1k
0
gravatar for GenoMax
4.4 years ago by
GenoMax96k
United States
GenoMax96k wrote:

There is ccmGDB. Web site appears to have moved to this new location.

ADD COMMENTlink written 4.4 years ago by GenoMax96k
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