Job: Postdoctoral Researcher - Bioinformatician/Computer Scientist- Earlham Institute (previously TGAC), UK
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Earlham Institute
Earlham Institute is a vibrant, contemporary research institute and registered charity, working in an area of rapid technological development and innovation.

Earlham Institute is strategically funded by the BBSRC to lead the development of a skill base in bioinformatics and a genomics technology platform for UK bioscience. The Institute is located on the Norwich Research Park, together with its partners: the John Innes Centre, the Institute of Food Research, The Sainsbury Laboratory, the University of East Anglia and the Norfolk and Norwich University Hospital. The research park has an excellent reputation for research in plant and microbial sciences, interdisciplinary environmental science and food, diet and health, to whichEarlham Institute contributes strengths in genomics and bioinformatics. Close links exist between the NRP partners and new opportunities for collaboration in exciting new initiatives are under development. The NRP recently received £26M of government investment to facilitate innovation and further develop infrastructure to attract science and technology companies to the Park to enhance the vibrant environment and realise economic impact from research investment.

Earlham Institute is a UK hub for innovative Bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. This has been boosted recently by an e-Infrastructure grant to expand the data storage capacity to a multi-petabyte unit, deploying a high performance cluster and large-memory server enabling the allocation of processes requiring several terabytes of computing memory.

Earlham Institute’s state of the art DNA sequencing facility operates multiple complementary technologies for data generation that provide the foundation for analyses furthering our fundamental understanding of genomes and how they function. We aim to be at the forefront of technological advances and are developing and implementing technologies to generate and analyse new types of data. We also develop novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational bioscience. Earlham Institute has one fully owned subsidiary, Genome Enterprise Ltd (GEL) via which it offers genomic and bioinformatics services on a trading basis and works with commercial providers on a partnership basis. Earlham Institute also receives specific funding to enable knowledge exchange programmes which are supported across the institute teams.

Post Number 1003122 Job Title Postdoctoral Researcher - Bioinformatician/Computer Scientist Closing Date 18 Nov 2016 Grade SC6 Starting Salary £30,750 - £37,750

Project Title The project will develop a community accessible, powerful computational toolkit for analysis of NGS datasets to study gene families.

Main purpose of the job • Use existing bioinformatics tools either developed at the Earlham institute or open source to analyse gene families • Build and test pipeline components in a cloud environment (Cyverse) • Use benchmarking datasets from wheat and Tsetse fly to investigate specific gene families, build this analysis into a publication • Provide documentation and workshop material to allow non-specialist access to the workflows

The project will develop a community accessible, powerful computational toolkit for analysis of NGS datasets to study gene families. The toolkit will leverage information from data to identify novel genic sequences missed by gene prediction software, identify gene annotation errors, and provide an interface for phylogenetic comparison of gene families from related species. Critically it will allow the user to identify members of gene families which are under selection, rapidly expanding or changing in function.

The project is a collaboration between Prof. Anthony Hall (Earlham Institute), Dr. Ritesh Krishna (IBM Research UK) and Dr. Alistair Darby (University of Liverpool) and will be based at the Earlham Institute. The Hall lab has recently moved to the Earlham institute, the current focus of the lab is investigating the genetic and epigenetic diversity in bread wheat. The lab also works on the function and underlying mechanism of the circadian clock in model and crop species. The Earlham Institute provides a young and exciting cutting-edge research environment. It applying state of the art technologies to understand biological systems through the application multi-disciplinary approaches including genomics and biological computing.

The post holder will hold a PhD in biological science with a focus on bioinformatics or computational biology, or plant science or computational science PhD with a focus on biology and possess the following skills and experience (E=essential, D=desirable):

•Knowledge of genome evolution and gene families (D). •Genome analysis, bioinformatics, building workflows (E) •Experience using cloud computing, for example Cyverse (E) •Experience in computational biology as associated with next generation sequence analysis or a related subject (E). •Good presentation and interpersonal skills (E). •Skills in building bioinformatics workflows (D).
•Knowledge of sequence data handling (D). •Able to deal effectively with international and national collaborations (D). •Experience delivering workshops (D).

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