Question: (Closed) Why is ribosomal protein taken as a reference for highly expressed genes
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gravatar for rehalabar08
4.2 years ago by
rehalabar080 wrote:

I am having problems in assimilating the concept of ribosomal protein being highly expressed and use of these set as a reference one to calculate codon adaptation index value. Why do we take ribosomal protein as highly expressed genes? After transcription we have mRNA, tRNA and rRNA (rRNA along with ribosomal protein form subunit). May be this question of mine is silly but where do these ribosomal protein come from prior to translation and yeah some say they are in the machinery and conserved so if that is the case why do we check the expression level. I am so confused and unable to get csatisfying answer to it.

gene • 1.1k views
ADD COMMENTlink written 4.2 years ago by rehalabar080

Hello rehalabar08!

We believe that this post does not fit the main topic of this site.

Not a bioinformatics question.

For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.

If you disagree please tell us why in a reply below, we'll be happy to talk about it.

Cheers!

ADD REPLYlink written 4.2 years ago by Michael Dondrup48k

This question arised when I was checking my results between highly expressed genes and lowly expressed genes. S software has been developed to calculate CAI in Bioinformatics.I am clear with the techniques but not clear with the idea.

ADD REPLYlink written 4.2 years ago by rehalabar080

You are in principle asking, why are ribosomal proteins highly expressed, from a bioinformatics perspective it should be sufficient that they are, and they are easily identified because they are highly conserved.

but where do these ribosomal protein come from prior to translation and yeah some say they are in the machinery and conserved so if that is the case why do we check the expression level.

This is a biological question even if it not quite sure what you are asking exactly. Therefore I conclude your confusion is coming from the biology behind not bioinformatics.

If you can rephrase your question in a way that the computational aspect becomes obvious, I can reopen it.

ADD REPLYlink modified 4.2 years ago • written 4.2 years ago by Michael Dondrup48k
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