ChIP-seq itself is not strand specific. The reads generated when performing ChIP-seq are strand specific, which is important. The reads do not indicate the location of the TF binding or histone modification, they are at the end of the fragment that includes the TF binding position. The fact that the reads on the two strands should be seperated by ~ the average fragment size of your library is an important quality check for the data.
- It's generally not strand specific.
- The antibody doesn't bind DNA, it binds a protein that binds DNA. Of course, the protein is typically binding to both strands of DNA (often one of the grooves), which goes back to point 1.