Question: List of known fusions
1
gravatar for Ron
3.5 years ago by
Ron990
United States
Ron990 wrote:

Hi all,

Is there any list of known fusions database besides the COSMIC data base ?

http://cancer.sanger.ac.uk/cosmic/fusion

Thanks,

Ron

rna-seq ngs next-gen fusion • 1.4k views
ADD COMMENTlink modified 23 months ago by pbpanigrahi190 • written 3.5 years ago by Ron990
0
gravatar for enxxx23
3.3 years ago by
enxxx23230
European Union
enxxx23230 wrote:

It is not clear what kind of fusions are you looking for. Are you looking for fusions which are known also in healthy people, like for example MSMB-NCOA4, TTY15-USP9Y, SLC45A4-ELK4?

Here are very few: http://54.84.12.177/PanCanFusV2/ http://203.255.191.229:8080/chimerdbv31/mindex.cdb

For example, here are fusions which have been found in healthy people and most likely these fusions are false-positives? https://github.com/FusionAnnotator/FusionAnnotator/blob/master/Hg19_CTAT_fusion_annotator_lib/GTEx_Recurrent_Blacklist_July222016.txt

ADD COMMENTlink written 3.3 years ago by enxxx23230
0
gravatar for pbpanigrahi
23 months ago by
pbpanigrahi190
pbpanigrahi190 wrote:

Hi

I think you can explore FusionSearch module of FusionHub, a web server that allow you to annotate your fusion genes across 28 datasets in a single go. Databases include Cosmic, ChimerKB, ChimerPUB, ChimerSEQ, ChiTaRS, Farecafe, TicDB, Tumor Fusion Portal, FusionCancer, ConjoinG and some other datasets from literature. A total of 28 different fusion resources can be searched for fusion information.

Different ways you can search, pair-wise, gene-wise and chromosome-wise. Besides these annotation, the server allows you to annotate your fusion gene w.r.t functional domain, kegg/biocyc pathways, any possibility of non-coding gene fusion etc.

Hope this helps. Please provide your feedback/bug which will help to improve the tool.

Thanks

Priyabrata

ADD COMMENTlink written 23 months ago by pbpanigrahi190
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