Job: Postdoctoral Associate - CANCER EVOLUTION, JAX-GM, Farmington, CT, USA
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3.2 years ago by
The Jackson Laboratory for Genomic Medicine
JAX-GM40 wrote:


ABOUT JAX-GM: Comprising 183,000 square feet of highly advanced, state-of-the-art laboratories and supporting facilities, the brand new JAX-GM conveniently sits midway between NYC and Boston in the heart of Connecticut. JAX-GM is part of an exciting $1.1 billion venture between the state of Connecticut and The Jackson Laboratory, an internationally-recognized research and educational institution with unparalleled genomic resources and research support services.

ABOUT THE POSITION: Dr. Roel Verhaak’s lab at The Jackson Laboratory for Genomic Medicine is currently seeking two recent graduates interested in investigating cancer and therapy resistance.

We are looking for a molecular biologists experienced in cell culture and lentiviral transfection who will be investigating the evolution of individual glioblastoma (GBM) cells using single cell barcoding technology and comprehensively characterized GBM model systems. The goal of this study is to trace clonal evolution in GBM, to evaluate the genomic properties of dominant, therapy resistant clones relative to therapy sensitive cells and to compare findings in model systems with observations from clinical tumors. The ideal candidate has affinity for data analysis but experience with sequencing data (-analysis) is not a requirement.

We are also looking for computational biologists or researchers from associated disciplines to strengthen our computational analysis group. We offer a wide range of projects, including studies of extrachromosomal DNA in the context of cancer evolution which involves long read sequencing analysis; DNA methylation and transcriptome single cells studies; nucleosome analysis; and longitudinal analysis of glioma patient samples.

ABOUT THE VERHAAK LAB: Our group is highly interdisciplinary and provides a collaborative and fast-paced environment on the forefront of cancer genomics, in a scientific environment that will suit every ambition. Our laboratory has been involved with (and has led) several studies of The Cancer Genome Atlas (Verhaak et al, Cancer Cell 2010; Brennan/Verhaak et al, Cell 2013; Brat/Verhaak et al, N Eng J Med 2015; Cecarelli et al, Cell 2016; Zheng et al, Cancer Cell 2016). Check out our Biorxiv preprints for more current work ( and The Jackson Lab for Genomic Medicine is home to a large number of postdocs both at the bench and the command line, with several world class PIs. Salary and benefits are highly competitive.

MINIMUM QUALIFICATIONS: • PhD in relevant field of study. • Background in cancer research and/or computational biology required. • At least 2 first author publications in peer-reviewed journals (including submitted manuscripts) required. • Research experience in one or more of these areas highly preferred: tumor evolution, therapy resistance, brain tumors, single cell sequencing.

Our Postdoctoral Associates enjoy distinct advantages, including: • A uniquely collaborative environment that fosters interdisciplinary “team science” without departmental barriers • Unparalleled genomic resources and superior research support services • Close interaction with our award-winning faculty members • Partnerships with leading universities and medical centers • Numerous courses and conferences focused on genetics, genomics and biomedicine • Exceptional benefits, ample time off and other valuable programs • Working for an institution that has repeatedly been voted among the top 15 “Best Places to work in Academia” in the world by readers of The Scientist

TO APPLY: Complete the application @


JAX began in 1929 with a small group of scientists dedicated to the emerging field of genetics. We now have over 1,700 scientists, technicians, and support staff, including over 50 Principle Investigators in five primary disease areas: cancer, reproductive biology, immunology, metabolic processes and neuroscience. Our fundamental contributions to biomedical research include cancer genetics and establishing the mouse as the premier research animal model. • Uncover more of our historic milestones, including the 26 Nobel prizes associated with our research, resources, and education • Read our latest news & insights for a glimpse at how we’re impacting the future of biomedicine • Follow the progress we’re making on our quest to improve human health via our recent research highlights

EEO: All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

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