Motif discovery using MEME
1
1
Entering edit mode
4.7 years ago
#### ▴ 220

So, I was using meme for motif discovery online (web based) and offline both version. I have used for the same set of sequences and I found that the e-values for the same motif sequences varies using meme offline and online version ,technically this shouldn’t be the case, any idea why the values are different??

meme motif conserved domain • 1.8k views
ADD COMMENT
0
Entering edit mode

The background frequencies used online and offline are same ?

ADD REPLY
0
Entering edit mode

As far as I know it performs denovo motif discovery without any reference , and the e-value states the statistical significance of motif in the given sequence data. I am not sure about the background frequencies you are asking for, can you elaborate? Thanks

ADD REPLY
0
Entering edit mode
4.7 years ago
Girolamo ▴ 140

Is the difference in terms of e-values huge? As far as I remember, the background is calculated by shuffling the sequences in the input, hence you can have a slight difference Are the versions(online and offline) the same?

ADD COMMENT

Login before adding your answer.

Traffic: 785 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6