Binding Affinity prediction

Question

[ashamscsoft]

I have a doubt whether ki and kd are same according to this link http://autodock.scripps.edu/faqs-help/faq/how-autodock-4-converts-binding-energy-kcal-mol-into-ki. And also according to this link there is a formula in this link like ln k(binding)=-ln K(inhibition). In this we have to prove lhs=rhs? Kindly anyone help

Answer 1

[Devon Ryan]

Err, the link says that ln k(binding) = -ln K(dissociation), which makes total sense. Ki is normally used to refer to the Kd of an inhibitor.

BTW, this isn't a bioinformatics question (it's pharmacology). Please post similar questions on the biology or chemistry stackexchanges.

Edit: Ack, my pharmacology was rusty, Ki is not the Kd of an inhibitor! Anyway, you can google this and it's off-topic.