City, country: Ostrava, Czech Republic
Laboratory and Institution information: The University of Ostrava is the fastest developing University in Czech Republic. Laboratory of Molecular protozoology at the Life Science Research Centre is focused on molecular biology and functional genomics of Trypanosomatidae. There are two main research directions in the laboratory: i) studies of biodiversity; and ii) analysis of virulent factors in Leishmania infection.
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1. PhD position in molecular genetics of protists
Requirements: Fluent English, experience in molecular biology and genetics. Basic bio-computing (e.g. genome and transcriptome analysis) and statistics experience are advantageous.
Job description:
Successful candidate is expected to continue the on-going project on characterization of molecular mechanisms determining protein translation in Blastocrithidia. This flagellate possesses a non-canonical nuclear genetic code with UGA reassigned to encode tryptophan, while UAG and UAA used for glutamate encoding as well as for bona fide termination. The molecular basis for the dual interpretation of UAG and UAA codons remains elusive. Genomic, transcriptomic, and proteomic analyses will be complemented by functional studies in this protist. This is a collaborative project with the Institute of Parasitology in České Budějovice.
Recent publication on the topic:
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2. PhD position in diversity and phylogenetics of protists
Requirements: Fluent English, experience in molecular biology and knowledge of molecular phylogenetic approaches. Basic bio-computing (e.g. genome and transcriptome analysis) and statistics experience are advantageous.
Job description:
Successful candidate is expected to screen the available collections of trypanosomatids to find and characterize novel lineages. These will be used in comparative genomic and transcriptomic analyses to trace evolution of parasitism (adaptations to new hosts and environmental conditions), bacterial endosymbionts, viruses, etc.
Recent publications on the topic:
- http://www.ncbi.nlm.nih.gov/pubmed/27593378
- http://www.ncbi.nlm.nih.gov/pubmed/27021793
- http://www.ncbi.nlm.nih.gov/pubmed/26980834
- http://www.ncbi.nlm.nih.gov/pubmed/26317207
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3. PhD position in molecular biology of Leishmania
Requirements: Fluent English, experience in molecular biology and genetics. Basic bio-computing (e.g. genome and transcriptome analysis) and statistics experience are advantageous.
Job description:
Successful candidate is expected to continue the on-going project aimed at identification and characterization of novel virulence factors in Leishmania infection. Genes of interest will be ablated by conventional or conditional approaches and the resulted lines will be investigated using the whole arsenal of modern molecular and cell biology methods in vitro and in vivo in mice and insect models. This is a collaborative project with the Department of Parasitology of Charles University in Prague.
Recent publications on the topic:
- http://www.ncbi.nlm.nih.gov/pubmed/27021793
- http://www.ncbi.nlm.nih.gov/pubmed/25461484
- http://www.ncbi.nlm.nih.gov/pubmed/27381333
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How to apply:
Interested applicants should e-mail a CV and a cover letter explaining their suitability and motivation for the position and previous experience to Dr. Vyacheslav Yurchenko by February 15th, 2017. E-mail: vyacheslav.yurchenko@osu.cz
For more information please visit http://www1.osu.cz/~yurchenko/
